HNF1α controls renal glucose reabsorption in mouse and man
نویسندگان
چکیده
Unité des Virus Oncogènes, URA 1644 CNRS, Département des Biotechnologies, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris CEDEX 15, 1Unité des Transports Epithéliaux, U426 INSERM, Faculté de Médecine Xavier Bichat, 16, rue Henri Huchard, 75870 Paris CEDEX 18, 2Service des Explorations Fonctionnelles, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, 3Institut de Biologie de Lille, EP 10 CNRS, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille and 4Unité de Pathologie Métabolique et Hormonale du Developpement U342 INSERM, Hôpital Saint-Vincent-de-Paul, 82 Avenue Denfert Rochereau, 75014 Paris, France
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The transcription factor HNF1α regulates expression of chloride-proton exchanger ClC-5 in the renal proximal tubule.
The Cl(-)/H(+) exchanger ClC-5 is essential for the endocytic activity of the proximal tubule cells and the tubular clearance of proteins filtered in the glomeruli. The mechanisms that regulate the expression of ClC-5 in general and its specific expression in the proximal tubule are unknown. In this study, we investigated the hypothesis that the hepatocyte nuclear transcription factor HNF1α, wh...
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